Chiral Binaphthyl LigandsDownload PDF
Catalysts modified by chiral binaphthyl derivatives are excellent chiral C2-symmetric inducers. They can catalyze the asymmetric epoxidation reaction of electron-deficient olefins with high catalytic activity and excellent enantio selectivity. The substrate involves α,β-unsaturated ketones, α,β-unsaturated carboxylic acid amides, α,β-unsaturated esters, etc . These class catalysts are beneficial in improving the selectivity of the optically active product. The symmetry axis can be rotated appropriately to meet a perspective between the chemical requirements in the different substrate with the bidentate ligand, which is particularly favored by asymmetric synthesis chemists.
J&K provides a variety of chiral binaphthyl ligands, including 3.3'- or 6.6'- halogen-substituted, 2.2'- di-substituted, 3.3'-di-substituted group, etc.
Ligand used to prepare a chiral zirconium catalyst in an asymmetric Strecker synthesis.
Ligand used in the zinc catalyzed enantioselective Hetero Diels-Alder reaction.
References  J. Am. Chem. Soc., 2000, 122, 762.  Org. Lett., 2002, 4, 4349.  Org. Lett., 2003, 5, 1091.