Azaindole is considered as a bioisostere of the indole. This is different from an indole only by an additional nitrogen atom in the ring which alters the distribution of electron density due to the interaction of the "π-electron-deficient" and "π-electron-excessive" rings.
This structural feature of azaindoles broadens their applications in drug discovery and material sciences. Azaindole derivatives exhibit significant biological effects such as anti-angiogenic activities, anti-tumor activities and antibacterial activities. 7-Azaindoles are of particular interest because of their ability to mimic purines in their role as hydrogen-bonding partners. Medicinal chemists often utilize the azaindole core in their drug designs and synthesis.
J&K provides novel, unique and cost-effective azaindoles and derivatives, to help chemists realize their innovative ideas.