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- November 30 2017
- November 15 2017
- October 30 2017
3BDO—A new autophagy inhibitor
MTOR, a central regulator of autophagy, is involved in cancer and cardiovascular and neurological diseases. Modulating the MTOR signaling balance could be of great significance for numerous diseases. In previous studies, Professor BaoXiang Zhao of Shandong University found a chemical small molecule , 3-Benzyl-5-((2-nitrophenoxy) methyl)–dihydrofuran-2(3H)-one (3BDO), that inhibited autophagy in human umbilical vein endothelial cells (HUVEC s) and neuronal cells. JK Scientific offers 3BDO as sole agent.
3BDO was more efficient than 3-MA as autophagy inhibitor
3BDO could dock on FKBP1A in the same sites (TYR82A and ILE56A) as Rapamycin
Figure 1: Conceptual schematic of 3BDO and FLJ11812 mechanism of action
|1914077||3BDO, 97%, Activator for mTOR, Autophagy inhibitor||890405-51-3||Pricing|
Reagents for Photoresists Synthesis
Photoresists are widely used in integrated circuits, semiconductor devices, touch screens and photovoltaic materials. As a professional supplier, J&K provides a variety of reagents for the synthesis of photoresists. Our products offer reliable quality and high performance and are available in different package sizes from grams to kilograms to meet your requirements from basic research to large-scale manufacturing.
Monomers for Photoresists:
|476032||1,3-Adamantanediacetic acid, 97%||17768-28-4||Pricing|
|313268||Chlorendic anhydride, 96%||115-27-5||Pricing|
|396012||Isobornyl acrylate, 93%, stabilized with 200 - 400 ppm MEHQ||5888-33-5||Pricing|
|609785||cis-5-Norbornene-exo-2,3-dicarboxylic anhydride, 96%||2746-19-2||Pricing|
Additives for Photoresists:
|908824||Butyl acetate, 99%||123-86-4||Pricing|
|277506||9-Fluorenylmethyl carbamate, 98%||84418-43-9||Pricing|
|126667||2-Hydroxyethyl methacrylate, 99%, stabilized with 100 ppm MEHQ||868-77-9||Pricing|
|496960||Trimethylolpropane trimethacrylate, 90%||3290-92-4||Pricing|
|512472||Bis(4-tert-butylphenyl)iodonium triflate, 98%||84563-54-2||Pricing|
|517519||Diphenyliodonium nitrate, 97%||722-56-5||Pricing|
Photoinitiator for Photoresists:
The trifluoromethylthio group (CF3S-) represents one of the most lipophilic substituents. It is well known that incorporation of the trifluoromethylthio group into small molecules greatly enhances their ability to cross lipid membranes and their absorption rate in vivo. In addition, the high electronegativity of the CF3S group significantly improves the small molecule’s stability in acidic environments. Thus, the trifluoromethylthio group has drawn special attention from the pharmaceutical and agrochemical industries for its use in isosetere-based drug design.
J&K offers trifluoromethylthiolating reagents developed by Qilong Shen’s group at Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences. There are two types of these new electrophilic reagents: Trifluoromethanesulfenates (Lu-Shen reagent) and N-trifluoromethylthiosaccharin (Shen reagent).
Macrocyclic compounds are important tools to study chemistry and supramolecular science.
They are in an indispensable position in molecular recognition, molecular assembly, and functional materials building and so on. As a professional supplier, J&K offers a complete inventory of macrocyclic compounds include:Heteracalixaromatics and Corona[n]arenes.
|1938034||Phenylcopper(III) perchlorate, 95%||1169706-62-0||Pricing|