- Latest Products
- June 17 2017
- October 01 2016
- September 15 2016
Organic Linkers for MOFs
Metal Organic Frameworks (MOFs) are compounds that form a class of crystalline materials with periodic network structures. They consist of inorganic metal centers (metal ions or metal clusters) coordinated to organic linkers. Due to their multiformity, porosity, tailorability and large specific surface area, they have attracted immense attention in many research areas such as gas adsorption storage, molecular separation, catalysis, sustained-release drugs and photoelectricity.
J&K provides organic linkers with high purity and reliable quality that are applicable to MOFs to help chemists realize their innovative ideas.
|404950||Acetylenedicarboxylic acid, 98%||142-45-0||Pricing|
|380913||1,3-Adamantanedicarboxylic acid, 97%||39269-10-8||Pricing|
|328187||2-Aminoterephthalic acid, 99%||10312-55-7||Pricing|
|159403||1,2,4-Benzenetricarboxylic acid, 98%||528-44-9||Pricing|
|1415094||Biphenyl-3,3',5,5'-tetracarboxylic acid, 99%||4371-28-2||Pricing|
|620880||2,2'-Bipyridine-5,5'-dicarboxylic acid, 98%||1802-30-8||Pricing|
|507784||5-Hydroxyisophthalic acid, 99%||618-83-7||Pricing|
|493510||4,5-Imidazoledicarboxylic acid, 99%||570-22-9||Pricing|
|222263||1,4-Naphthalenedicarboxylic acid, 98%||605-70-9||Pricing|
|128551||Nitroterephthalic acid, 98%||610-29-7||Pricing|
|347052||1,10-Phenanthroline monohydrate, 99%||5144-89-8||Pricing|
|113992||2,6-Pyridinedicarboxylic acid, 99%||499-83-2||Pricing|
|495317||4-(4-Pyridyl)benzoic acid, 99%||4385-76-6||Pricing|
Leiker - a new cross-linker for MS of large protein complexes
Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) has emerged as a powerful tool for the analysis of complex protein structures and protein-protein interactions. CXMS methods are less time-consuming and less demanding of sample purity than are traditional methods; this technology has thus been increasing in popularity. It does not typically work well, however, on complex samples that contain many different proteins, as it is difficult to separate the cross-linked peptides from the overwhelming amounts of non cross-linked peptides.
J&K Scientific, as a professional supplier, is proud to offer a new cross-linker called Leiker that addresses this limitation. Leiker makes possible the efficient and effective CXMS of large protein complexes.
Leiker enables effective enrichment of cross-linked peptides.
Figure 1. Leiker allowed near 100% enrichment of target peptides from a cross-linked ten-protein mixture diluted with increasing amounts of non-cross-linked E. coli lysates.
Crosslinking efficiency is higher than BS3.
Figure 2. CXMS analyses of E. coli and C. elegans lysates. The best protein-protein interaction cluster extracted from the Leiker-identified or BS3-identified (Yang et al., 2012) inter-links from E. coli whole-cell lysates.
Leiker-based quantitative CXMS analysis
Figure 3. Quantitative CXMS analysis of the L7Ae-RNA complex. Reciprocal labeling of RNA-free (F) and RNA-bound (B) L7Ae with [d0]/[d6]-Leiker.
Leiker-based quantitative CXMS analysis
 Tan and Li, et al. eLife 2016; 5:e12509
 Yang, et al. Nature Methods 2012; 9:904–906.
Nano-microspheres are particles that range in size from 5nm to 1000μm. They are widely used as drug carriers, enzyme carriers, conductive balls or magnetic beads in biological pharmaceuticals, food safety testing and medical diagnostics.
- Easy surface modification
- Large specific surface area
- Excellent biocompatibility
- Good stability in physiological medium
Reagents for Protein Structure Analysis
With the completion of the Human Genome Project (HGP), the focus of biological science has turned from Genomics to Proteomics. The investigation of protein structure and function has emerged as an exciting research area in the post-genome era. Such as incorporation of selenium atoms into proteins has been a staple method for protein crystallography. Methionine (Met) can be replaced by Selenomethionine (SeMet) in this process by means of isomorphous substitution without any negative effect.
|929073||Dabsyl chloride, 98%, derivatization grade||56512-49-3||Pricing|
|164579||5-Dimethylamino-1-naphthalenesulfonyl chloride, 98%||605-65-2||Pricing|
|158799||Poly(ethylene glycol), average M.W. 6,000||25322-68-3||Pricing|
|105893||Sodium dodecyl sulfate, 99%, for biochemistry||151-21-3||Pricing|