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New Products

J&K Scientific is committed to research and innovation. We are proud of our independent new product achievements as well as our development partnership with our customers and distributors. For many years J&K has invited companies to collaborate and share in market opportunities by contributing and co-developing products. Our product range grows every year with thousands of new compounds and derivatives added to our existing list of over 500,000 ultrafine materials, pharmaceutical chemicals, biochemicals and specialty chemical products for science and industry.
  • Latest Products
  • October 30 2017
  • July 17 2017
  • June 17 2017

Trifluoromethylthiolating Reagents

The trifluoromethylthio group (CF3S-) represents one of the most lipophilic substituents. It is well known that incorporation of the trifluoromethylthio group into small molecules greatly enhances their ability to cross lipid membranes and their absorption rate in vivo. In addition, the high electronegativity of the CF3S group significantly improves the small molecule’s stability in acidic environments. Thus, the trifluoromethylthio group has drawn special attention from the pharmaceutical and agrochemical industries for its use in isosetere-based drug design.

J&K offers trifluoromethylthiolating reagents developed by Qilong Shen’s group at Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences. There are two types of these new electrophilic reagents: Trifluoromethanesulfenates (Lu-Shen reagent) and N-trifluoromethylthiosaccharin (Shen reagent).

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Feathered Products:

structure Product no. description cas pricing
254810 Bis(phenylsulfonyl)sulfide, 96% 4388-22-1 Pricing
1784571 3,3-Dimethyl-1-?(trifluoromethylthio)-1,2-benziodoxole, 95% 1584705-82-7 Pricing
1784574 (2-Phenylpropan-2-yloxy)(trifluoromethyl)sulfane, 98% 1640084-14-5 Pricing
1784566 2-(Trifluoromethylthio)isoindoline-1,3-dione, 98% 719-98-2 Pricing
1784565 1-(Trifluoromethylthio)pyrrolidine-2,5-dione, 98% 183267-04-1 Pricing
1784567 N-Trifluoromethylthiosaccharin, 98% 1647073-46-8 Pricing

Macrocyclic Compounds

Macrocyclic compounds are important tools to study chemistry and supramolecular science.

They are in an indispensable position in molecular recognition, molecular assembly, and functional materials building and so on. As a professional supplier, J&K offers a complete inventory of macrocyclic compounds include:Heteracalixaromatics and Corona[n]arenes.

Related Products
catalysts and Ligands
Literature
Anhydrous Solvents
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Feathered Products:

structure Product no. description cas pricing
1938032 Dichloro-diazadioxacalix[2]arene[2]triazine, 95% 51421-67-1 Pricing
1938035 Hexabromo-O6-corona[3]arene[3]tetrazine, 95% 1642594-07-7 Pricing
1938031 Dichloro-oxacalix[2]arene[2]triazine, 95% 819065-56-0 Pricing
1938033 Tetraazacalix[4]pyridine, 95% 502763-15-7 Pricing
1938034 Phenylcopper(III) perchlorate, 95% 1169706-62-0 Pricing
1938036 Hexester-O6-corona[3]arene[3]tetrazine, 95% 1642594-08-8 Pricing

Organic Linkers for MOFs

Metal Organic Frameworks (MOFs) are compounds that form a class of crystalline materials with periodic network structures. They consist of inorganic metal centers (metal ions or metal clusters) coordinated to organic linkers. Due to their multiformity, porosity, tailorability and large specific surface area, they have attracted immense attention in many research areas such as gas adsorption storage, molecular separation, catalysis, sustained-release drugs and photoelectricity.

J&K provides organic linkers with high purity and reliable quality that are applicable to MOFs to help chemists realize their innovative ideas.

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Feathered Products:

structure Product no. description cas pricing
404950 Acetylenedicarboxylic acid, 98% 142-45-0 Pricing
380913 1,3-Adamantanedicarboxylic acid, 97% 39269-10-8 Pricing
328187 2-Aminoterephthalic acid, 99% 10312-55-7 Pricing
159403 1,2,4-Benzenetricarboxylic acid, 98% 528-44-9 Pricing
1415094 Biphenyl-3,3',5,5'-tetracarboxylic acid, 99% 4371-28-2 Pricing
620880 2,2'-Bipyridine-5,5'-dicarboxylic acid, 98% 1802-30-8 Pricing
507784 5-Hydroxyisophthalic acid, 99% 618-83-7 Pricing
493510 4,5-Imidazoledicarboxylic acid, 99% 570-22-9 Pricing
222263 1,4-Naphthalenedicarboxylic acid, 98% 605-70-9 Pricing
128551 Nitroterephthalic acid, 98% 610-29-7 Pricing
347052 1,10-Phenanthroline monohydrate, 99% 5144-89-8 Pricing
113992 2,6-Pyridinedicarboxylic acid, 99% 499-83-2 Pricing
495317 4-(4-Pyridyl)benzoic acid, 99% 4385-76-6 Pricing
348905 1,3,5-Triethynylbenzene, 98% 7567-63-7 Pricing
493973 2,4,6-Tris(4-carboxyphenyl)-1,3,5-triazine, 97% 61414-16-2 Pricing

Leiker - a new cross-linker for MS of large protein complexes

Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) has emerged as a powerful tool for the analysis of complex protein structures and protein-protein interactions. CXMS methods are less time-consuming and less demanding of sample purity than are traditional methods; this technology has thus been increasing in popularity. It does not typically work well, however, on complex samples that contain many different proteins, as it is difficult to separate the cross-linked peptides from the overwhelming amounts of non cross-linked peptides[1].

J&K Scientific, as a professional supplier, is proud to offer a new cross-linker called Leiker that addresses this limitation. Leiker makes possible the efficient and effective CXMS of large protein complexes.

Leiker enables effective enrichment of cross-linked peptides.





Figure 1. Leiker allowed near 100% enrichment of target peptides from a cross-linked ten-protein mixture diluted with increasing amounts of non-cross-linked E. coli lysates.

Crosslinking efficiency is higher than BS3.





Figure 2. CXMS analyses of E. coli and C. elegans lysates. The best protein-protein interaction cluster extracted from the Leiker-identified or BS3-identified (Yang et al., 2012) inter-links from E. coli whole-cell lysates.

Leiker-based quantitative CXMS analysis





Figure 3. Quantitative CXMS analysis of the L7Ae-RNA complex. Reciprocal labeling of RNA-free (F) and RNA-bound (B) L7Ae with [d0]/[d6]-Leiker.

Leiker-based quantitative CXMS analysis


[1] Tan and Li, et al. eLife 2016; 5:e12509
[2] Yang, et al. Nature Methods 2012; 9:904–906.

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Feathered Products:

structure Product no. description cas pricing
2138035 Leiker, 95% Pricing
2322681 d6-Leiker, 95% Pricing

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