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The trifluoromethylthio group (CF3S-) represents one of the most lipophilic substituents. It is well known that incorporation of the trifluoromethylthio group into small molecules greatly enhances their ability to cross lipid membranes and their absorption rate in vivo. In addition, the high electronegativity of the CF3S group significantly improves the small molecule’s stability in acidic environments. Thus, the trifluoromethylthio group has drawn special attention from the pharmaceutical and agrochemical industries for its use in isosetere-based drug design.
J&K offers trifluoromethylthiolating reagents developed by Qilong Shen’s group at Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences. There are two types of these new electrophilic reagents: Trifluoromethanesulfenates (Lu-Shen reagent) and N-trifluoromethylthiosaccharin (Shen reagent).
Macrocyclic compounds are important tools to study chemistry and supramolecular science.
They are in an indispensable position in molecular recognition, molecular assembly, and functional materials building and so on. As a professional supplier, J&K offers a complete inventory of macrocyclic compounds include:Heteracalixaromatics and Corona[n]arenes.
|1938034||Phenylcopper(III) perchlorate, 95%||1169706-62-0||Pricing|
Organic Linkers for MOFs
Metal Organic Frameworks (MOFs) are compounds that form a class of crystalline materials with periodic network structures. They consist of inorganic metal centers (metal ions or metal clusters) coordinated to organic linkers. Due to their multiformity, porosity, tailorability and large specific surface area, they have attracted immense attention in many research areas such as gas adsorption storage, molecular separation, catalysis, sustained-release drugs and photoelectricity.
J&K provides organic linkers with high purity and reliable quality that are applicable to MOFs to help chemists realize their innovative ideas.
|404950||Acetylenedicarboxylic acid, 98%||142-45-0||Pricing|
|380913||1,3-Adamantanedicarboxylic acid, 97%||39269-10-8||Pricing|
|328187||2-Aminoterephthalic acid, 99%||10312-55-7||Pricing|
|159403||1,2,4-Benzenetricarboxylic acid, 98%||528-44-9||Pricing|
|1415094||Biphenyl-3,3',5,5'-tetracarboxylic acid, 99%||4371-28-2||Pricing|
|620880||2,2'-Bipyridine-5,5'-dicarboxylic acid, 98%||1802-30-8||Pricing|
|507784||5-Hydroxyisophthalic acid, 99%||618-83-7||Pricing|
|493510||4,5-Imidazoledicarboxylic acid, 99%||570-22-9||Pricing|
|222263||1,4-Naphthalenedicarboxylic acid, 98%||605-70-9||Pricing|
|128551||Nitroterephthalic acid, 98%||610-29-7||Pricing|
|347052||1,10-Phenanthroline monohydrate, 99%||5144-89-8||Pricing|
|113992||2,6-Pyridinedicarboxylic acid, 99%||499-83-2||Pricing|
|495317||4-(4-Pyridyl)benzoic acid, 99%||4385-76-6||Pricing|
Leiker - a new cross-linker for MS of large protein complexes
Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) has emerged as a powerful tool for the analysis of complex protein structures and protein-protein interactions. CXMS methods are less time-consuming and less demanding of sample purity than are traditional methods; this technology has thus been increasing in popularity. It does not typically work well, however, on complex samples that contain many different proteins, as it is difficult to separate the cross-linked peptides from the overwhelming amounts of non cross-linked peptides.
J&K Scientific, as a professional supplier, is proud to offer a new cross-linker called Leiker that addresses this limitation. Leiker makes possible the efficient and effective CXMS of large protein complexes.
Leiker enables effective enrichment of cross-linked peptides.
Figure 1. Leiker allowed near 100% enrichment of target peptides from a cross-linked ten-protein mixture diluted with increasing amounts of non-cross-linked E. coli lysates.
Crosslinking efficiency is higher than BS3.
Figure 2. CXMS analyses of E. coli and C. elegans lysates. The best protein-protein interaction cluster extracted from the Leiker-identified or BS3-identified (Yang et al., 2012) inter-links from E. coli whole-cell lysates.
Leiker-based quantitative CXMS analysis
Figure 3. Quantitative CXMS analysis of the L7Ae-RNA complex. Reciprocal labeling of RNA-free (F) and RNA-bound (B) L7Ae with [d0]/[d6]-Leiker.
Leiker-based quantitative CXMS analysis
 Tan and Li, et al. eLife 2016; 5:e12509
 Yang, et al. Nature Methods 2012; 9:904–906.