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Derivatization Reagents

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Derivatization is the process by which a compound is chemically changed, producing a new compound that has properties more amenable to a particular analytic technique. As a key separation method, derivatization provides: ●Increased volatility, thermal stability, and peak shape ●Improved selectivity and chromatographic efficiency ●Strengthened detectability

J&K provides an extensive selection of Derivatization Reagents, including those used for GC and HPLC analysis, chiral separations and TLC applications. By choosing the right derivatization reagent and procedure you can increase resolution and analytic response, significantly improving your separations.

■ GC Derivatization Reagents

GC Derivatization Reagents include silylation reagents, acylation reagents, esterification & alkylation reagents and others.

● Silylation

structure Product no. description cas pricing
247763 Bis(dimethylamino)dimethylsilane, 97% 3768-58-9 Pricing
447636 N,O-Bis(trimethylsilyl)acetamide, 95% 10416-59-8 Pricing
576242 N,O-Bis(trimethylsilyl)trifluoroacetamide, 98% 25561-30-2 Pricing
472228 Bromotrimethylsilane, 98% 2857-97-8 Pricing
296944 N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide, 97% 77377-52-7 Pricing
305146 Chloro(chloromethyl)dimethylsilane, 98% 1719-57-9 Pricing
584711 Dichlorodiethylsilane, 97% 1719-53-5 Pricing
333396 N,N-Dimethyltrimethylsilylamine, 97%, derivatization grade 2083-91-2 Pricing
543142 Heptamethyldisilazane, 98% 920-68-3 Pricing
123746 N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 97% 24589-78-4 Pricing
585626 1,1,3,3-Tetramethyldisilazane, 97% 15933-59-2 Pricing
600909 N-Trimethylsilylimidazole, 98% 18156-74-6 Pricing

●Acylation

structure Product no. description cas pricing
411631 1-Acetylimidazole, 98% 2466-76-4 Pricing
535607 Bistrifluoroacetamide, 98% 407-24-9 Pricing
219537 Heptafluorobutyric acid, 99% 375-22-4 Pricing
120251 Heptafluorobutyric anhydride, 98% 336-59-4 Pricing
100530 1-(Heptafluorobutyryl)imidazole, 97% 32477-35-3 Pricing
313895 (±)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid, 97% 81655-41-6 Pricing
254934 N-Methyl-bis(trifluoroacetamide), 98% 685-27-8 Pricing
370486 1-(Trifluoroacetyl)imidazole, 97.5%, derivatization grade 1546-79-8 Pricing

●Esterification & Alkylation

structure Product no. description cas pricing
101363 2,2-Dimethoxypropane, 98% 77-76-9 Pricing
113009 N,N-Dimethylformamide diethyl acetal, 95%, derivatization grade 1188-33-6 Pricing
191255 N,N-Dimethylformamide dimethyl acetal, 95% 4637-24-5 Pricing
221715 Methyl trifluoromethanesulfonate, 96% 333-27-7 Pricing
457936 Tetramethylammonium hydroxide, 25% solution in H2O 75-59-2 Pricing
379130 3-(Trifluoromethyl)phenyltrimethylammonium hydroxide, 5% solution in MeOH 68254-41-1 Pricing
533891 (Trimethylsilyl)diazomethane, 2.0 M solution in hexanes 18107-18-1 Pricing
518558 Trimethylsulfonium hydroxide, 0.25 M solution in MeOH 17287-03-5 Pricing

● Others

structure Product no. description cas pricing
532517 n-Butylboronic acid, 97.5% 4426-47-5 Pricing
369954 O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride, 99%, derivatization grade 57981-02-9 Pricing

■ HPLC Derivatization Reagents

HPLC Derivatization Reagents are organized by detection method, including UV, Fluorescence and Chemiluminescence detections.

●UV Detection

structure Product no. description cas pricing
112138 Benzenesulfonyl chloride, 99% 98-09-9 Pricing
579741 Benzoyl chloride, 99% 98-88-4 Pricing
366373 2-Bromoacetophenone, 99% 70-11-1 Pricing
288843 2-Bromo-4'-phenylacetophenone, 98% 135-73-9 Pricing
154661 (-)-10-Camphorsulfonic acid, 99% 35963-20-3 Pricing
562385 4-(N-Chloroformylmethyl-N-methylamino)-7-nitro-2,1,3-benzoxadiazole, 92%, derivatization grade 140164-85-8 Pricing
929073 Dabsyl chloride, 98%, derivatization grade 56512-49-3 Pricing
279588 2,4'-Dibromoacetophenone, 98% 99-73-0 Pricing
439198 Dimedone, 98% 126-81-8 Pricing
121011 4-Dimethylaminobenzoyl chloride, 97% 4755-50-4 Pricing
164579 5-Dimethylamino-1-naphthalenesulfonyl chloride, 98% 605-65-2 Pricing
168708 1,3-Dinitrobenzene, 99% 99-65-0 Pricing
343109 3,5-Dinitrobenzoyl chloride, 99% 99-33-2 Pricing
610866 2,4-Dinitrophenylhydrazine, 98%, wetted with ca. 50% water 119-26-6 Pricing
128686 9-Fluorenylmethyl carbazate, 98%, derivatization grade 35661-51-9 Pricing
197308 9-Fluorenylmethyl chloroformate, 98% 28920-43-6 Pricing
136896 Hydroxylamine hydrochloride, 98.5% 5470-11-1 Pricing
508752 Marfey's reagent, 98% 95713-52-3 Pricing
376516 4-Methoxybenzoyl chloride, 99% 100-07-2 Pricing
563564 Methyl isothiocyanate, 98% 556-61-6 Pricing
343352 3-Methyl-1-phenyl-2-pyrazolin-5-one, 98% 89-25-8 Pricing
586813 N-Methylphthalimide, 98% 550-44-7 Pricing
201896 1-Naphthyl isocyanate, 99%, derivatization grade 86-84-0 Pricing
249447 1-Naphthyl isothiocyanate, 98%, derivatization grade 551-06-4 Pricing
205431 4-Nitrobenzoyl chloride, 98% 122-04-3 Pricing
603426 4-Nitrobenzyl bromide, 99% 100-11-8 Pricing
368359 N-(4-Nitrophenylacetoxy)succinimide, 98%, derivatization grade,for HPLC Labeling 68123-33-1 Pricing
210054 2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate, 98% 14152-97-7 Pricing
405140 Phenyl isothiocyanate, 98%, for sequential analysis 103-72-0 Pricing
227585 o-Phthalaldehyde, 99% 643-79-8 Pricing
333410 N-(1-Pyrenyl)maleimide, 97% 42189-56-0 Pricing
135775 Salicylaldehyde, 99% 90-02-8 Pricing
283322 p-Toluenesulfonyl chloride, 99% 98-59-9 Pricing
417912 m-Toluoyl chloride, 98.5% 1711-06-4 Pricing

●Fluorescence Detection

●Chemiluminescence detection

structure Product no. description cas pricing
482541 N-(4-Aminobutyl)-N-ethylisoluminol, 97% 66612-29-1 Pricing
227560 2,3-Dihydro-6-isothiocyanato-1,4-phthalazinedione, 96% 107807-39-6 Pricing

■ Chiral Derivatization Reagents

●Chiral GC Derivatization Reagents

structure Product no. description cas pricing
189438 (-)-Camphanic acid chloride, 98% 39637-74-6 Pricing
571643 (R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid, 98%, ee: 99.5% 20445-31-2 Pricing
192146 (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid, 98% 17257-71-5 Pricing
191106 (S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride, 99% 20445-33-4 Pricing
313066 (S)-(-)-α-Methylbenzyl isocyanate, 98%, for chiral derivatization 14649-03-7 Pricing
241739 (R)-(+)-1-(1-Naphthyl)ethylamine, 99% 3886-70-2 Pricing
390305 (S)-(-)-1-(1-Naphthyl)ethylamine, 99% 10420-89-0 Pricing
238277 L-(-)-2-Octanol, 99% 5978-70-1 Pricing
297184 D-(+)-2-Octanol, 99% 6169-06-8 Pricing
457038 (R)-(+)-1-Phenylethanol, 99%, for chiral derivatization 1517-69-7 Pricing
284516 (S)-(-)-1-Phenylethanol, 99%, for chiral derivatization 1445-91-6 Pricing
138277 (R)-(+)-1-Phenylethylamine, 99% 3886-69-9 Pricing
134448 (S)-(-)-1-Phenylethylamine, 99%, ee: 98% 2627-86-3 Pricing

●Chiral LC Derivatization Reagents

structure Product no. description cas pricing
485835 (+)-10-Camphorsulfonic acid, 99% 3144-16-9 Pricing
433825 L-(-)-10-Camphorsulfonyl chloride, 98% 39262-22-1 Pricing
215457 Boc-L-cysteine, 99%, for chiral derivatization 20887-95-0 Pricing
497970 (R)-(-)-N-(3,5-Dinitrobenzoyl)-α-phenylglycine, 98% 74927-72-3 Pricing
198485 (R)-(-)-O-Formylmandeloyl chloride, 98% 29169-64-0 Pricing
107382 (R)-(-)-α-Methoxyphenylacetic acid, 99% 3966-32-3 Pricing
441219 (S)-(+)-α-Methoxyphenylacetic acid, 99%, for chiral derivatization 26164-26-1 Pricing
356622 (-)-α-Methylbenzyl isothiocyanate, 98%, for chiral derivatization 24277-44-9 Pricing
260251 R-(+)-1-Phenyl-1-propanol, 98% [ee:90%] 1565-74-8 Pricing

■ TLC Derivatization Reagents

structure Product no. description cas pricing
199896 p-Anisaldehyde, 99% 123-11-5 Pricing
552604 Bromocresol Green, ACS reagent 76-60-8 Pricing
602425 4-Dimethylaminobenzaldehyde, 99% 100-10-7 Pricing
280243 5-(4-Dimethylaminobenzylidene)rhodanine, 97% 536-17-4 Pricing
149895 Iodine, 99.8%, ACS reagent 7553-56-2 Pricing
122337 Ninhydrin, ACS reagent 485-47-2 Pricing
216624 1,3,3-Trimethyl-2-methyleneindoline, 95% 118-12-7 Pricing
188374 Vanillin, 99% 121-33-5 Pricing

■MS Derivatization Reagents

structure Product no. description cas pricing
220778 2-Aminobenzamide, 98% 88-68-6 Pricing
148928 O-(Carboxymethyl)hydroxylamine hemihydrochloride, 98%, derivatization grade 2921-14-4 Pricing
154090 2-Fluoro-1-methylpyridinium p-toluenesulfonate, 98% 58086-67-2 Pricing
341056 Girard's Reagent P, 98% 1126-58-5 Pricing
509681 Girard's Reagent T, 98% 123-46-6 Pricing
476922 2-Hydrazinopyridine, 97% 4930-98-7 Pricing
432347 2-Nitrophenylhydrazine hydrochloride, 98%, derivatization grade 6293-87-4 Pricing
303168 p-Toluenesulfonyl isocyanate, 96% 4083-64-1 Pricing