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Four Membered Ring Compounds

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Highly reactive four-membered ring compounds including cyclobutane ,oxetane, azetidine .They are useful substrates in organic chemistry due to the functionalization of the different positions of the ring which can be used to design and preparation of biologically active compounds. For example, L-azetidine-2-carboxylic acid(237409) is an inhibitor of collagen synthesis as anti-angiogenic. The best-known examples of oxetane-containing drugs are the natural product paclitaxel (Taxol?) and its synthetic analog docetaxel. Jo?lle Dubois and co-workers studied the effect of the deletion of the oxetane ring in analogs of docetaxel and found the analogs were less active than docetaxel in biological assays.

The four-membered ring compounds have become standard elements of the repertoire of chemists in drug discovery. This has resulted in an strong growth of the number of journals or patents across a wide range of applications.

J&K can offer a variety of four-membered ring compounds in different package sizes from grams to kilograms. All these products have sufficient stock,and are known for their excellent quality and competitive prices.

■ Cyclobutanes & Cyclobutenes

structure Product no. description cas pricing
155198 Bromocyclobutane, 97% 4399-47-7 Pricing
144311 Cyclobutylamine, 98% 2516-34-9 Pricing
268029 Cyclobutanol, 98.5% 2919-23-5 Pricing
270250 Cyclobutanone, 98% 1191-95-3 Pricing
435231 (Bromomethyl)cyclobutane, 98.5% 17247-58-4 Pricing
233989 Cyclobutanemethanol, 98.5% 4415-82-1 Pricing
181953 Cyclobutanecarboxylic acid, 98% 3721-95-7 Pricing
168489 3-Oxo-cyclobutanecarboxylic acid, 95% 23761-23-1 Pricing
380229 1,1-Cyclobutanedicarboxylic acid, 99% 5445-51-2 Pricing
311369 3,4-Dihydroxy-3-cyclobutene-1,2-dione, 99% 2892-51-5 Pricing
184022 3,4-Dimethoxy-3-cyclobutene-1,2-dione, 99% 5222-73-1 Pricing
491805 3,4-Dibutoxy-3-cyclobutene-1,2-dione, 98% 2892-62-8 Pricing
108051 3,4-Diethoxy-3-cyclobutene-1,2-dione, 98% 5231-87-8 Pricing

■ Oxetanes

structure Product no. description cas pricing
835702 Oxetan-3-one, 95% 6704-31-0 Pricing
996513 β-Propiolactone, 98%, research grade 57-57-8 Pricing
430627 3-Ethyl-3-oxetanemethanol, 98% 3047-32-3 Pricing
439836 N-Boc-L-serine β-lactone, 98% 98541-64-1 Pricing

■ Azetidines

structure Product no. description cas pricing
246240 Azetidine, 95% 503-29-7 Pricing
474517 Azetidine hydrochloride, 99% 36520-39-5 Pricing
172318 Azetidine-3-carboxylic acid, 98% 36476-78-5 Pricing
563718 3-Hydroxyazetidine hydrochloride, 97% 18621-18-6 Pricing
237409 L-Azetidine-2-carboxylic acid, 98% 2133-34-8 Pricing
804022 Azetidine-3-carbonitrile hydrochloride, 97% 345954-83-8 Pricing
336714 1-Boc-3-azetidinone, 98% 398489-26-4 Pricing
129471 1-Boc-azetidine-3-carboxylic acid, 97% 142253-55-2 Pricing
104410 1-Boc-3-aminoazetidine, 95% 193269-78-2 Pricing
260134 1-Benzhydryl-azetidine-3-carbonitrile, 97% 36476-86-5 Pricing
616566 1-(Diphenylmethyl)-3-hydroxyazetidine, 98% 18621-17-5 Pricing